Naptumomab estafenatox
Naptumomab estafenatox is an antibody drug conjugate pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against trophoblast glycoprotein.
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Commercial
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Naptumomab estafenatox |
| INN | naptumomab estafenatox |
| Description | Naptumomab estafenatox (mouse Fab) |
| Classification | Antibody |
| Drug class | aptamers, classical and mirror; monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743045 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 93T929W6LC (ChemIDplus, GSRS) |
Target
Agency Approved
TPBG
TPBG
Organism
Homo sapiens
Gene name
TPBG
Gene synonyms
5T4
NCBI Gene ID
Protein name
trophoblast glycoprotein
Protein synonyms
5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, WAIF1, Wnt-activated inhibitory factor 1
Uniprot ID
Mouse ortholog
Tpbg (21983)
trophoblast glycoprotein (Q9Z0L0)
Alternate
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Trends
PubMed Central
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Safety
Black-box Warning
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10 adverse events reported
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